Flavoured nicotine powder inhaler

ABSTRACT

This disclosure relates to flavoured nicotine powder inhalers where the nicotine powder is delivered at air flow rates that mimic a smoking regime.

This application is a continuation of U.S. application Ser. No.15/124,592, filed 8 Sep. 2016, which is a § 371 U.S. National Stage ofInternational Application No. PCT/IB2015/001283, filed 23 Apr. 2015,which claims the benefit of U.S. Provisional Application No. 61/984,968,filed 28 Apr. 2014 and EP Application No. 14166210.6, filed 28 Apr.2014, each of which are incorporated by reference herein.

This disclosure relates to flavoured nicotine powder inhalers, where theflavoured nicotine powder is delivered at low air flow rates.

Dry powder inhalers (DPI) are known and are used to treat respiratorydiseases by delivering a dry powder comprising a pharmaceutical, inaerosol form through inhalation to the patients' airways. For deliverydeep into the lungs, particles in the range of 1 to 5 micrometers arerequired. In pharmaceutical dry powders, the active pharmaceuticalingredient (API) is agglomerated on the surface of larger carrierparticles, e.g. lactose, and DPI's therefore operate complex mechanismsto ensure such agglomerates disperse, break up or disaggregate beforethe API can be inhaled deep into the lungs. Pharmaceutical dry powderscontaining lactose as a carrier are typically in the range of 20 to 100micrometers. Existing DPI's for example first “grind” or de-agglomeratethe dry powder or impact the larger particles of the dry powder toresult in the aforementioned particle size range.

DPI's rely on the force of the patients' inhalation to entrain thepowder from the device to subsequently break-up the powder intoparticles that are small enough to enter the lungs. Sufficiently highinhalation rates are required to ascertain correct dosing and completedisaggregation of the powder. Typically a large amount of API remainsattached on the surface of the carrier and is deposited in the upperairways due to incomplete de-aggregation of the powder. Inhalation ratesof existing DPI's are usually in the range of 40-120 liters/min (L/min).Existing DPI's are therefore only suitable for delivering dry powders tousers in a manner that is different from the inhalation rate associatedwith smoking articles.

It would be desirable to provide a flavoured nicotine powder inhalerthat can deliver flavoured nicotine powder to a user at inhalation orair flow rates that are within conventional smoking regime inhalation orair flow rates. It would be desirable to provide a flavoured nicotinepowder inhaler that is a similar size and configuration as aconventional cigarette. It would be desirable to provide a flavourednicotine powder inhaler that can provide a metered dose of flavourednicotine and an optional simultaneous delivery of a second activeingredient.

Flavoured nicotine powder inhalers of the invention described herein canbe utilized to deliver flavoured nicotine to a user at inhalation or airflow rates that are close to or within conventional smoking regimeinhalation or air flow rates. The flavoured nicotine powder inhalers canprovide a predictable and metered dose of flavoured nicotine or otheroptional active ingredients. Flavoured nicotine powder inhalers of theinvention described herein have a similar size and configuration as aconventional cigarette and have a simple configuration.

As described herein, a flavoured nicotine powder inhaler includes a bodyextending between a mouthpiece and a distal end portion and an airflowchannel extends along the body of the inhaler. A nicotine powderreceptacle along the airflow channel holds a dose of nicotine powder. Aflavour delivery element is in fluid communication with the airflowchannel. The dose of nicotine powder can be inhaled into lungs of a userat an inhalation rate of less than about 5 L/min or preferable less thanabout 2 L/min. Preferably the dose of nicotine powder is a nicotine saltcontained in a capsule that can be pierced by the inhaler.

Various aspects of the flavoured nicotine powder inhalers describedherein may have one or more advantages relative to standard dry powderinhalers. For example, the flavoured nicotine powder inhalers deliverthe dry powder nicotine and the flavour particles at inhalation or airflow rates that are within conventional smoking regime inhalation or airflow rates and inhalation manner. This allows users with evencompromised or impaired breathing conditions to successfully deliver thedry powder nicotine and flavourant. The flavoured nicotine powderinhalers described herein have a simplified configuration that allowsthe user to predetermine the metered dose of dry powder nicotine andflavourant. The dry powder nicotine can be in series or in parallel flowrelation with the flavour delivery element. The flavourant can be a drypowder or a liquid flavourant. Additional advantages of one or moreaspects flavour delivery system described herein will be evident tothose of skill in the art upon reading and understanding the presentdisclosure.

The term “nicotine” refers to nicotine and nicotine derivatives such asnicotine salts.

The term “flavourant” or “flavour” refers to organoleptic compounds,compositions, or materials that alter the taste or aroma characteristicsof nicotine during consumption or inhalation thereof.

The present disclosure provides flavoured nicotine powder inhalers forinhaling dry powder nicotine and flavourant. The flavoured nicotinepowder inhalers include a body extending between a mouthpiece portionand a distal end portion. An airflow channel extends between themouthpiece portion and a distal end portion and a nicotine powderreceptacle. The nicotine powder receptacle is disposed along the airflowchannel and is configured to receive a dose of nicotine powder. Aflavour delivery element is in fluid communication with the airflowchannel. The dose of nicotine powder can be inhaled into lungs of a userat an inhalation rate of less than about 5 L/min or less than about 2L/min which mimics the inhalation flow rate utilized for a conventionalsmoking regime. The flavourant is delivered to the mouth of the usersimultaneously as the nicotine particles are inhaled. The flavourednicotine powder inhalers described herein are “passive” devices thatutilize only the inhalation air flow created by the lungs of a user tocreate air flow though the body of the flavoured nicotine powderinhaler.

The airflow path or airflow channel through the body of the inhaler is asimple path or channel. In many embodiments the airflow path or airflowchannel through the body of the inhaler is parallel to a longitudinalaxis of the inhaler and is linearly extending along an entire length ofthe inhaler body. In some embodiments the inhaler includes two or threeco-extensive airflow channels. One, two or all three of the airflowchannels can include a capsule receptacle. In some embodiments the oneor more airflow paths or airflow channels includes a swirl generatorelement that is configured to induce a rotational movement of theairflow moving through the body of the inhaler. The swirl generatorelement can discharge into an outlet channel that can be a larger volumethan the one or more individual airflow paths or airflow channels.

The nicotine powder receptacle and the flavour delivery element areconfigured and arranged to provide the nicotine powder and theflavourant simultaneously. In some embodiments the flavourant is a drypowder mixed with the nicotine powder in a capsule, for example. Inother embodiments the flavourant is separated from the nicotine powderbefore inhalation or mixing within the airflow channels of the inhaler.In some of these embodiments the flavourant and the nicotine powder arein serial flow arrangement and disposed within a single flow channel andthe flavourant or flavour delivery element is either upstream ordownstream of the nicotine powder or nicotine powder receptacle. Inother embodiments the flavourant and the nicotine powder are in parallelflow arrangement and disposed within a pair of flow channels where theflavourant and the nicotine powder combine to form a mixture downstreamof both the nicotine powder receptacle and the flavour delivery element.

The nicotine powder receptacle can receive a capsule of nicotine powder.The capsule can contain a predetermined amount or dose of nicotinepowder and optional flavourant. In many embodiments the capsule cancontain enough nicotine powder to provide at least 2 inhalations or“puffs” of nicotine powder, or at least about 5 inhalations or “puffs”of nicotine powder, or at least about 10 inhalations or “puffs” ofnicotine powder. In many embodiments the capsule can contain enoughnicotine powder to provide from about 5 to 50 inhalations or “puffs” ofnicotine powder, or from about 10 to 30 inhalations or “puffs” ofnicotine powder. Each inhalation or “puff” of nicotine powder candeliver from about 0.5 mg to about 3 mg of nicotine powder to the lungsof the user or from about 1 mg to about 2 mg of nicotine powder to thelungs of the user or about 1 mg of nicotine powder to the lungs of theuser.

In many embodiments the capsule holds or contains at least about 5 mg ofnicotine powder or at least about 10 mg of nicotine powder. In manyembodiments the capsule holds or contains less than about 30 mg ofnicotine powder or less than about 25 mg of nicotine powder, or lessthan 20 mg of nicotine powder. In many embodiments the capsule holds orcontains from about 5 mg to about 30 mg of nicotine powder or from about10 mg to about 20 mg of nicotine powder.

In embodiments that include the flavourant blended or combined with thenicotine powder within the capsule, the flavourant is present in anamount that provides the desired flavour to each inhalation or “puff”delivered to the user.

The capsule can be formed of an airtight material that can be pierced orpunctured by the inhaler. The capsule can formed of a metallic orpolymeric material that serves to keep contaminates out of the capsulebut can be pierced or punctured by the inhaler during use.

The inhaler can include a piercing element or pair of opposing piercingelements that are configured to pierce the capsule of nicotine powder.The piercing element or pair of opposing piercing elements fluidlyconnect the airflow channel with the dose of nicotine powder. Thepiercing element or pair of opposing piercing elements can engage withthe capsule of nicotine powder upon loading the capsule of nicotinepowder into the nicotine powder receptacle or upon demand by an actuatoron the body of the inhaler.

In many embodiments the nicotine powder is a pharmaceutically acceptablenicotine salt or nicotine salt hydrate. Useful nicotine salts ornicotine salt hydrates include nicotine bitartrate, nicotine salicylate,nicotine fumarate, nicotine mono-pyruvate, nicotine glutamate ornicotine hydrochloride, for example. The compound combining withnicotine to form the salt or salt hydrate can be chosen based on itspharmacological effect. For example: nicotine salicylate can beadministered for fever relief, as an anti-inflammatory or painkiller;nicotine fumarate can be administered to treat multiple sclerosis; andnicotine mono-pyruvate can be administered for treating chronicobstructive pulmonary disease (COPD) or for weight loss.

The nicotine powder can have any useful size distribution for inhalationdelivery into the lungs of a user. In many embodiments at least about 90wt % of the nicotine powder has a particle size of about 10 micrometersor less, preferably about 7 micrometers or less. The nicotine powderpreferably has a mean average diameter size range from about 0.1 toabout 10 micrometers, more preferably from about 1 to about 7micrometers, even more preferably from about 2 to 6 about micrometers.

Conventional formulations for dry powder inhalation typically containcarrier particles that serve to increase the fluidization of the activeparticles since the active particles are typically too small to beinfluenced by the airflow though the inhaler. The carrier particles thuswere utilized to improve the dose uniformity by acting as a diluent orbulking agent in a formulation. However, the nicotine powder describedherein can be carrier-free. Being carrier-free allows the nicotinepowder and to be inhaled and delivered to the user's lungs at inhalationor airflow rates that are similar to typical smoking regime inhalationor airflow rates. In addition, since the nicotine powder iscarrier-free, the airflow path of the inhaler can have simple geometryor a simple configuration.

The nicotine powder described herein can be a surface modified nicotinesalt where the nicotine salt particle is a coated particle. Onepreferred coating material is L-leucine. These carrier-free nicotinepowders are described and are available from Teicos Pharma Inc., Espoo,Finland. One particularly useful nicotine powder is an L-luecine coatednicotine bitartrate.

Flavourants or flavours can be provided as liquid or solid flavours (atroom temperature of about 22 degrees centigrade and one atmospherepressure) and can include flavour formulations, flavour-containingmaterials and flavour precursors. The flavourant may include one or morenatural flavourants, one or more synthetic flavourants, or a combinationof natural and synthetic flavourants.

Flavourants or flavours refer to a variety of flavour materials ofnatural or synthetic origin. They include single compounds and mixtures.Preferably the flavour or flavourant has flavour properties that enhancethe experience of the nicotine powder inhaler to, for example, providean experience similar to that resulting from smoking a combustiblesmoking article. For example, the flavour or flavourant can enhanceflavour properties such as mouth fullness and complexity. Complexity isgenerally known as the overall balance of the flavour being richerwithout dominating single sensory attributes. Mouth fullness isdescribed as perception of richness and volume in the mouth and throatof the consumer.

Suitable flavours and aromas include, but are not limited to, anynatural or synthetic flavour or aroma, such as tobacco, smoke, menthol,mint (such as peppermint and spearmint), chocolate, licorice, citrus andother fruit flavours, gamma octalactone, vanillin, ethyl vanillin,breath freshener flavours, spice flavours such as cinnamon, methylsalicylate, linalool, bergamot oil, geranium oil, lemon oil, and gingeroil, and the like.

Other suitable flavours and aromas may include flavour compoundsselected from the group consisting of an acid, an alcohol, an ester, analdehyde, a ketone, a pyrazine, combinations or blends thereof and thelike. Suitable flavour compounds may be selected, for example, from thegroup consisting of phenylacetic acid, solanone, megastigmatrienone,2-heptanone, benzylalcohol, cis-3-hexenyl acetate, valeric acid, valericaldehyde, ester, terpene, sesquiterpene, nootkatone, maltol,damascenone, pyrazine, lactone, anethole, iso-s valeric acid,combinations thereof, and the like.

Further specific examples of flavours may be found in the currentliterature, for example, in Perfume and Flavour Chemicals, 1969, by S.Arctander, Montclair N.J. (USA); Fenaroli's Handbook of FlavourIngredients, CRC Press or Synthetic Food Adjuncts by M. B. Jacobs, vanNostrand Co., Inc. They are well-known to the person skilled in the artof flavouring, i.e. of imparting an odor or taste to a product.

In some embodiments, the flavourant is a high potency flavourant, and istypically used at levels that would result in less than 200 parts permillion in inhalation air flow. Examples of such flavourants are keytobacco aroma compounds such as beta-damascenone,2-ethyl-3,5-dimethylpyrazine, phenylacetaldehyde, guaiacol, andfuraneol. Other flavourants can only be sensed by humans at higherconcentration levels. These flavourants, which are referred to herein asthe low potency flavourants, are typically used at levels that resultsin orders of magnitude higher amounts of flavourant released into theinhalation air. Suitable low potency flavourants include, but are notlimited to, natural or synthetic menthol, peppermint, spearmint, coffee,tea, spices (such as cinnamon, clove and ginger), cocoa, vanilla, fruitflavours, chocolate, eucalyptus, geranium, eugenol and linalool.

The flavour delivery element can be in the form of a capsule containingthe flavourant. The capsule can be ruptured by mechanical force such asbeing squeezed or crushed by a use's fingers or other mechanical meansactivated by the user. The flavourant within the flavour capsule ispreferably a liquid flavourant. The flavour capsule can be disposedupstream of the nicotine powder receptacle, but it is preferablydownstream of the nicotine powder receptacle. The flavour capsule can bedisposed in a filter element.

The flavour delivery element can be a thread element impregnated byflavourant. Preferably the flavourant in these embodiments is menthol.The thread can be disposed in a filter element that is preferablyupstream of the nicotine powder receptacle.

The filter element containing the flavour delivery element can be formedof filtering material such as conventional cellulose acetate filteringmaterial. The filtering material can be a plug of filtering materialwrapped in paper or plug wrap. The filtering material can be upstream ordownstream of the flavour delivery element, preferably the filteringmaterial is disposed both upstream or downstream of the flavour deliveryelement. In some embodiments the flavour delivery element extendsthrough the filtering material.

A second active agent or ingredient can be delivered along with theflavoured nicotine powder. The second active agent or ingredient can bemixed with the nicotine in the capsule or separate from the nicotine inits own capsule. The second active agent or ingredient can be fluidizedwith the flavoured nicotine powder and inhaled by a user.

This second active agent or ingredient can be any active pharmaceuticalmaterial. In many embodiments the second active agent or ingredient canbe combined with the nicotine powder and flavourant described herein byblending the materials during inhalation. The nicotine powder,flavourant and the second active agent or ingredient can be blended inthe same capsule or provided in series in a single air flow channel inthe DPI or provided in parallel in separate flow channels of the DPI.The second active agent or ingredient can have a similar mean averagediameter size range as the nicotine powder described above.

The flavoured nicotine powder inhaler is less complex and has asimplified powder storage and airflow path as compared to existing DPIs,and does not need a carrier ingredient, such as lactose, as describedabove. Therefore the complex mechanisms to dissociate/disaggregate apharmaceutical dry powder is not required in the described flavourednicotine inhaler and therefore the described nicotine inhaler operatesunder low airflow. The inhaler does not require the typical highinhalation rates of conventional DPIs to deliver the dry nicotinepowders described above deep into the lungs.

The flavoured nicotine inhaler according to this invention operatesusing a flow rate of less than about 5 L/min or less than about 3 L/minor less than about 2 L/min or about 1.6 L/min. In many embodiments theflow rate is in a range from about 1 L/min to about 3 L/min or fromabout 1.5 L/min to about 2.5 L/min. In preferred embodiments theinhalation rate or flow rate is similar to that of Health Canada smokingregime, that is about 1.6 L/min. In contrast, a conventional DPIoperates at a flow rate of about 40-120 L/min and often requires anenergy source or propellant to promote air flow to achieve this air flowrate.

The flavoured nicotine inhaler described herein can be used by aconsumer like smoking a conventional cigarette or vaping an electroniccigarette. Such smoking or vaping is characterized by two steps: a firststep during which a small volume containing the full amount of nicotinedesired by the consumer is drawn into the mouth cavity, followed by asecond step during which this small volume comprising the aerosolcomprising the desired amount of nicotine is further diluted by freshair and drawn deeper into the lungs. Both steps are controlled by theconsumer. During the first inhalation step the consumer can determinethe amount of nicotine to be inhaled. During the second step, theconsumer can determine the volume for diluting the first volume to bedrawn deeper into the lungs, maximizing the concentration of activeagent delivered to the airway epithelial surface. This smoking mechanismis sometimes called “puff-inhale-exhale”.

All scientific and technical terms used herein have meanings commonlyused in the art unless otherwise specified. The definitions providedherein are to facilitate understanding of certain terms used frequentlyherein.

The terms “upstream” and “downstream” refer to relative positions ofelements of the inhaler described in relation to the direction ofinhalation air flow as it is drawn through the body of the inhaler froma distal end portion to the mouthpiece portion.

As used herein, the singular forms “a”, “an”, and “the” encompassembodiments having plural referents, unless the content clearly dictatesotherwise.

As used herein, “or” is generally employed in its sense including“and/or” unless the content clearly dictates otherwise. The term“and/or” means one or all of the listed elements or a combination of anytwo or more of the listed elements.

As used herein, “have”, “having”, “include”, “including”, “comprise”,“comprising” or the like are used in their open ended sense, andgenerally mean “including, but not limited to”. It will be understoodthat “consisting essentially of”, “consisting of”, and the like aresubsumed in “comprising,” and the like.

The words “preferred” and “preferably” refer to embodiments of theinvention that may afford certain benefits, under certain circumstances.However, other embodiments may also be preferred, under the same orother circumstances. Furthermore, the recitation of one or morepreferred embodiments does not imply that other embodiments are notuseful, and is not intended to exclude other embodiments from the scopeof the disclosure, including the claims.

FIGS. 1-11 are schematic diagrams of illustrative flavoured nicotinepowder inhalers 10. FIGS. 3-7 are shown with transparent bodies for easeof illustration of the flow channels and internal elements. Theschematic drawings are not necessarily to scale and are presented forpurposes of illustration and not limitation. The drawings depict one ormore aspects described in this disclosure. However, it will beunderstood that other aspects not depicted in the drawing fall withinthe scope and spirit of this disclosure.

Referring now to FIG. 1 and FIG. 2, the flavoured nicotine powderinhalers 10 include a mouthpiece portion 12 and a distal end portion 14and a nicotine capsule 20 disposed between them. Piercing elements 11Aand 11B are configured to pierce the capsule 20 and fluidly connect theairflow channel 13 of the mouthpiece portion 12 with the airflow channel15 of the distal end portion 14. The airflow channel extends linearlyalong a length of the nicotine powder inhaler 10. FIG. 2 furtherillustrates the capsule 20 within a receptacle 25 that can be re-usable.A flavour delivery element can be upstream, downstream or within thecapsule 20.

FIG. 3 and FIG. 4 illustrate flavoured nicotine powder inhalers 10having a single linear airflow channel 13, 15. Piercing elements 11A and11B extend into a nicotine powder receptacle 30 and are configured topierce the nicotine powder capsule and fluidly connect the airflowchannel 13 of the mouthpiece portion 12 with the airflow channel 15 ofthe distal end portion 14. The airflow channel extends linearly along alength of the nicotine powder inhaler 10 from a proximal mouthpiece end18 to a distal end 19. The mouthpiece portion 12 can connect with thedistal end portion 14 via a bayonet-type connection. In FIG. 3 themouthpiece portion 12 is not symmetrical with the distal end portion 14.In FIG. 4 the mouthpiece portion 12 is symmetrical with the distal endportion 14. A flavour delivery element can be disposed along the airflowchannel 13, 15 and can be pierced with the piercing elements 11A and 11Bor separate set of piercing elements, not illustrated.

FIG. 5 and FIG. 6 is a further illustrative flavoured nicotine powderinhaler 10 having multiple airflow channels 15. FIG. 6 is a view of FIG.5 taken along lines 6-6. This embodiment includes three airflow channels15 and a first, second and third powder receptacles 30, 32 and 33respectively. A nicotine powder capsule and flavour capsule can bereceived in at least one of the powder receptacles 30, 32 and 33. Insome embodiments, a second active agent can be received in at least oneof the powder receptacles 30, 32 and 33. The three flow channels 15fluidly connect to an outlet channel 40 via a swirl generator 50configured to induce rotation movement in the airflow. The airflowchannels 15 extend linearly along a length of the flavoured nicotinepowder inhaler 10 from a proximal mouthpiece end 18 to a distal end 19.A ventilation element 70 can be disposed along an airflow channels 15 toprovide dilution air, as desired.

FIG. 7 is a further illustrative flavoured nicotine powder inhaler 10.This embodiment includes three airflow channels 15A, 15B and 15C andfirst, second and third powder receptacles 30, 32 and 33 respectively. Anicotine powder capsule and flavour capsule can be received in at leastone of the powder receptacles 30, 32 and 33. In some embodiments, asecond active agent can be received in at least one of the powderreceptacles 30, 32 and 33. The three flow channels 15 fluidly connect toan outlet channel 40 via a swirl generator 50 configured to inducerotation movement in the airflow. The airflow channels 15A, 15B extendlinearly along a length of the flavoured nicotine powder inhaler 10 froma proximal mouthpiece end 18 to a distal end 19. In some embodiments anairflow loop element 60 is disposed along an airflow channels 15C.

FIGS. 8-11 illustrate schematic diagrams of flavoured inhalers 10. FIG.8 shows a flavoured nicotine inhaler 10 having a single flow path and asingle capsule 120 containing both the powdered nicotine and flavourant,preferably a powdered flavourant. The air flow path includes an upstreamportion 15 and a downstream portion 13.

FIG. 9 shows a flavoured nicotine inhaler 10 having a single flow pathand a nicotine capsule 20 containing powdered nicotine in serial flowarrangement with the flavourant capsule 100, preferably a powderedflavourant. In some embodiments the flavourant capsule 100 contains aliquid flavourant. In many of these embodiments the flavourant capsule100 can be ruptured by a user to release the liquid flavourant, asdescribed above. The liquid flavourant is preferably downstream of thenicotine capsule 20. The air flow path includes an upstream portion 15and a downstream portion 13.

FIG. 10 shows a flavoured nicotine inhaler 10 having a parallel flowpath and a nicotine capsule 20 containing powdered nicotine in parallelflow arrangement with the flavourant capsule 100, preferably a powderedflavourant. In some embodiments the flavourant capsule 100 contains aliquid flavourant. The flavourant capsule 100 can be pierced asdescribed above for the nicotine capsule 20. The air flow path includesan upstream portion 15 and a downstream portion 13.

FIG. 11 shows a flavoured nicotine inhaler 10 having a single flow pathand a nicotine capsule 20 containing powdered nicotine in serial flowarrangement with the flavour delivery element 130. The flavour deliveryelement 130 can be a filter element having a thread impregnated withflavourant, preferably liquid flavourant. The nicotine capsule 20 ispreferably downstream of the filter element providing the flavourant.The air flow path includes an upstream portion 15 and a downstreamportion 13.

1. A nicotine powder inhaler comprising: a body extending between aproximal mouthpiece end and a distal end; a nicotine powder receptacledisposed within the body; a swirl generator element disposed in the bodyand constructed to induce rotational movement in the airflow movingthrough the body; an outlet airflow channel extending from the swirlgenerator to an outlet at the proximal mouthpiece end; and a pluralityof airflow channels fluidly connected to the proximal mouthpiece end viathe swirl generator element; wherein the inhaler is constructed todeliver a dose of nicotine powder via air flow created by inhalation atthe proximal mouthpiece end at an inhalation rate of less than about 5L/min.
 2. A nicotine powder inhaler according to claim 1, wherein theoutlet channel has a volume being greater than a volume of the airflowchannels.
 3. A nicotine powder inhaler according to claim 1, furthercomprising a piercing element configured to extend into the nicotinepowder receptacle.
 4. A nicotine powder inhaler according to claim 1,wherein the airflow channels comprise three airflow channels.
 5. Anicotine powder inhaler according to claim 1, comprising a cylindricalmouthpiece portion.
 6. A nicotine powder inhaler according to claim 1,wherein the nicotine powder receptacle defines a cylindrical shape.
 7. Anicotine powder inhaler according to claim 1, wherein the body has atransverse cross-section shape having a major axis and a minor axis, andthe major axis is longer than the minor axis.
 8. A system for providingnicotine powder, the system comprising the nicotine powder inhaler ofclaim 1 and further comprising a capsule containing nicotine powder, thecapsule disposed within the nicotine powder receptacle.
 9. The system ofclaim 8, wherein the capsule further comprises a flavourant powder. 10.The system of claim 8, wherein the capsule further comprises an activeagent.
 11. The system of claim 8, wherein the nicotine powder has a meanaverage particle size in a range from 1 micrometer to 7 micrometers. 12.The system of claim 11, wherein at least 90% of the nicotine powder hasa particle size of 7 micrometers or less.
 13. The system of claim 8,wherein the nicotine powder comprises L-Leucine.
 14. The system of claim8, wherein the nicotine powder comprises nicotine bitartrate.
 15. Thesystem of claim 8, wherein the nicotine powder comprises nicotineglutamate.
 16. The system of claim 8, wherein nicotine comprises anamount of nicotine powder sufficient to deliver from 10 to 30inhalations of nicotine, each inhalation of nicotine comprising 0.5 mgto 3 mg of nicotine.
 17. A method of inhaling nicotine into lungs of auser: inhaling air through the system of claim 6 at a flow rate of lessthan about 2 L/min to deliver powder nicotine into lungs of a user. 18.The method of claim 17, wherein the inhaling air through the systeminduces rotational movement of air flowing through the nicotine powderinhaler.
 19. The method of claim 17, wherein the inhaling air throughthe system induces rotational movement of air flowing through thenicotine powder inhaler and delivers nicotine powder and flavourantpowder into lungs of a user.